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Natural Health Glossary
Medical Terms, Therapies, Accreditation

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luteolin
A yellow crystalline compound that is a flavonoid and used as dyestuff. It is so named because it can be obtained from the foliage of the dyer's broom (Reseda luteola). It is thought to play a role in the human body possibly as an antioxidant, a free radical scavenger, a promoter of carbohydrate metabolism, or an immune system modulator.

Preliminary research results indicate luteolin as an anti-inflammatory agent with potential effects on septic shock and cancer. It has been suggested for multiple sclerosis on the basis of in vitro work.

Luteolin is a plant-based substance that is most often found in leaves, but it is also seen in rinds, barks, clover blossom, and ragweed pollen. Dietary sources include celery, green pepper, thyme, dandelion, perilla, chamomile tea, carrots, olive oil, peppermint, rosemary, navel oranges and oregano.

Luteolin has been shown to inhibit skin cancer mechanisms in vitro and in vivo. Other research has found it to be a PDE4 inhibitor, phosphodiesterase inhibitor, and an interleukin 6 inhibitor, affecting xylazine/ketamine-induced anesthesia in mice.
Warnings: Gastrointestinal adverse effects, such as nausea, vomiting and gastric hypersecretion, may occur.

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