| Share: | more

Health News and Information - Natural. Healthy. Canadian.

Gedunin, a novel natural substance, inhibits ovarian cancer cell proliferation

Photo: neem tree

In vitro treatment of ovarian cancer cell lines with gedunin (an extract of the neem tree) alone produced up to an 80% decrease in ovarian cancer cell proliferation


2009-12-19

From the PubMed 19955938 study abstract:

The discovery of more active therapeutic compounds is essential if the outcome for patients with advanced-stage epithelial ovarian cancer is to be improved. Gedunin, an extract of the neem tree, has been used as a natural remedy for centuries in Asia.

Recently, gedunin has been shown to have potential in vitro antineoplastic properties; however, its effect on ovarian cancer cells is unknown. We evaluated the in vitro effect of gedunin on SKOV3, OVCAR4, and OVCAR8 ovarian cancer cell lines proliferation, alone and in the presence of cisplatin. Furthermore, we analyzed in vitro gedunin sensitivity data, integrated with genome-wide expression data from 54 cancer cell lines in an effort to identify genes and molecular pathways that underlie the mechanism of gedunin action.

In vitro treatment of ovarian cancer cell lines with gedunin alone produced up to an 80% decrease in cell proliferation (P < 0.01) and, combining gedunin with cisplatin, demonstrated up to a 47% (P < 0.01) decrease in cell proliferation compared with cisplatin treatment alone. Bioinformatic analysis of integrated gedunin sensitivity and gene expression data identified 52 genes to be associated with gedunin sensitivity.

These genes are involved in molecular functions related to cell cycle control, carcinogenesis, lipid metabolism, and molecular transportation. We conclude that gedunin has in vitro activity against ovarian cancer cells and, further, may enhance the antiproliferative effect of cisplatin. The molecular determinants of in vitro gedunin response are complex and may include modulation of cell survival and apoptosis pathways.

Kamath SG, Chen N, Xiong Y, Wenham R, Apte S, Humphrey M, Cragun J, Lancaster JM. Division of Gynecologic Surgical Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, USA.


2009-12-19

RSS News Feeds:
 All NHC News  Industry News  Health Canada Alerts  Nutrition News

Information on this website is for information purposes only.
Please consult a qualified health practitioner before taking any course of action.
Always check for counter-results before deciding on a course of action.

+Other NHC news:
Blog post: Understanding Our Editorial Choices, by Gisela McKay
At the computer for long periods? Find information and prevention tools
Workplace Wellness Programs: bring healthy ideas to your workplace...
Bio Intolerance Elimination: An exciting new approach to allergy relief
Read the #naturalhealth incanada Daily! [news] Click here for news, recipes, opinions from Canadian naturalhealth practitioners.


Find us:

twitter facebook LinkedIn Blog Blog Find us on Pinterest Find us on Youtube